Sounds to me that Windows has its read caching turned off somehow or your hard drive configuration / performance is way below par??
Typically if you start an app, and close it, if you immediately restart it, it's usually way faster because parts of it are still cached in RAM, this sounds to me like something is turned off in your configs or similar.
Now if all the other programs on the machine starts okay then maybe it is IExplorer settings or something.
-Will
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