Hi ed, this is the first I've heard of a problem like this so I have no idea at all what might be happening right now.

Can you please generate a system report after you try to run it (something like this: http://support.kaspersky.com/2854) and e-mail that to me at moi@moi3d.com ? Maybe that will have some kind of debug information from Wineskin.

Also check your \tmp folder to make sure that there are not any odd permissions set on it, if your permissions have become messed up that can potentially cause weird problems.

- Michael