Hi ethos, there are a lot of people running MoI under Win7 64-bit, so there isn't any general problem with that. And I would not think that a large monitor size would make any difference, just make sure you have a video card with plenty of video RAM on it.

Do you have any anti-virus or anti-spyware type systems running on your machine? Maybe one of those is interfering with things, can you try temporarily disabling them and see if that makes any difference?

Does the same thing happen with the alternate trial version? You can download that one from here:
http://moi3d.com/2.0/trial/moi_v2_nosave_trial_setup.exe

The 30-day trial version has an anti-cracking protection layer around it but the alternate "no-save" trial version does not have that, so if the alternate trial version works that means there is some problem with the anti-cracking mechanism on your computer.

- Michael