I'm running Windows 8 RTM on my main workstation (Windows 7 was totally hosed and I needed to do a clean install anyway).

So far I've had no issues with any major software, including MOI. The only thing that's had an issue is my Dataplex SSD caching software. When it's installed it makes my registry read-only and I can no longer install or uninstall anything.

Otherwise I've found it to be a nice OS. It's different, but honestly I don't see what all the whining is about. The start menu is actually still there, you just go to the bottom left of your screen and right-click. Otherwise you can use the start window with the tiles.

I personally just use Launchy and don't worry about either one.

-Paul