Hi PaQ - definitely if you're using more kind of "painting" type software that uses more brush stroke motions it is much more natural for that.

But just regular mouse pointer manipulation like clicking on buttons tends to be weird for a while at least if you have spent a long long time using a mouse instead only.

Hi Eric,
Some say "OHYEAH!!!" and some say "Yeachhhhh!!!!"

I would suggest finding one somewhere at you local computer store or something and try it. They arent cheap so the effort to track one down first is a good investment. (Unless you can afford a $400 Yeachhh!)

Don't miss to try Artrage with a tablet!
That is Zen paintintg for sure! Even with the free version!
http://www.ambientdesign.com/

Thanks everyone ...

I have not drawn with a pencil for a very long time ... as soon as CAD became available for small architectural offices I jumped into it. I have been using a mouse ever since and it sounds like I should just stay with it ... I do find MoI easy to use with a mouse ... my hand knows what to do and would be awkward with a pencil now.

cheers
eric