I would be very surprised if it runs - right now MoI uses several different Windows subsystems that are pretty complex, such as Direct3D, mshtml.dll, and COM interprocess marshaling.
MoI won't run unless there is a very high quality emulation provided for every one of these complex systems. I think that WINE is more complete in the emulation of just the basic core Win32 API - I doubt that they emulate mshtml.dll very well for example.
I guess anything is possible, but I wouldn't get your hopes up...
- Michael
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