Hi ingoenius, I don't think that WINE will work because they don't do a very good emulation of some of the libraries that MoI uses such as mshtml.dll .
I don't know much about VirtualBox, but I don't think it supports Direct3D, which MoI needs.
On a Mac, some people have been successful running MoI with recent versions of Parallels and VMware.
I think that VMWare has a Linux version, so that may be one possible way to get it to work. That is probably your best bet.
- Michael
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