Hi Javier, I've just been doing some testing with High Sierra to try and figure it out.

Please try the following:

Right-click the MoI app and choose "Show package contents".

Inside there run the Wineskin.app

On the dialog that pops up, click the "Set screen options" button.

Uncheck the option for "Auto Detect GPU info for Direct3D" and then push "Done".

Push "Quit".

Restart your machine to make sure no previous instances of MoI with other settings are running.

Now try running MoI again.

Any better? - Michael