Sorry to take so long to follow up on this. I asked the question, then had a string of personal biz to deal with that kept me away from MoI time for a bit.
I'm using a basic, wired, Logitech wheel mouse. The only mouse driver is the Apple driver that comes with OS 10.12.6. The only suspicious thing I noticed in my control panel was a legacy driver for a Griffin iMate that I used on an earlier system to provide ADB access via the USB port. These things follow from system to system via the "migration" helper. It seemed to be inactive, but I've removed it now. Still seeing the behavior but I have yet to reboot. Will do so now and report back in a bit.
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