Hi Mike

This seems a typical sub-d workflow..you did this model in C4D right?
I think you know -Hypernurbs-tool in C4D:put your sharp low poly model as child of hypernurbs and you'll get a smooth rounded shape
Doing this in Nurbs need a different approach:draw contour lines and then choose which tool to use
As Michael says is not clear what you want to fillet and what not
better to post a hand-sketch ;)