Hi mjs,

> <update> Found a way to cause a failure in one way. Depending on how close to the ends
> of each edge you are when you select. This is something I don't normally run into as I always
> try to pick the near the points that I want to have lofted together. However, in the case of this
> file the two open holes have different numbers of edges. The smaller one has 4 edges while the
> larger one has 8 edges. If you pick closer to the "wrong" end of the little short edges you can
> get strange twisting or even a failure now and then.

There isn't anything in edge to edge blend that's trying to do different things depending on which side you selected on.

Is it possible that on one of those "wrong side" selections that you accidentally selected one of the other edges like this one here? :




Over here I've been trying all sorts of different selection orders and click sides and I haven't been able to get a single bad result...

- Michael