1) Look at KeyShot render with the Animation option. The latest version of KeyShot has a "toon" shader that gives a very nice illustration quality to 3D models, and you can easily animate your models within KeyShot. Sample toon shader animation: http://keyshot.com/forum/index.php/topic,6409.0.html
2) If you want to just move 2D images around and animate some connecting lines and text, Adobe After Effects alone will work well.