Hi Sean, the introductory videos here give a good overview of the basic strategy, which is about drawing some principle profile curves, using those profiles to construct some shapes and to apply cuts, combining different shapes together with booleans and using fillets to round off sharp edges:
http://moi3d.com/2.0/docs/tutorials.htm

Really the main way to sum up the strategy in a simple way is that you should be forming large portions of your model from a relatively small number of 2D profile curves.

Check out here for some links to discussions and general tips for people who are coming from a sub-d / poly modeling background:
http://moi3d.com/forum/index.php?webtag=MOI&msg=4865.2

- Michael