OK - I tried on my desktop and I get an inkling that things might work under the perfect storm of circumstances. Here is what I get:

phr0stbyte@Phr0styBox:~/.wine/drive_c/Program Files/MoI 3.0 beta Aug-24-2011$ wine MoI.exe
fixme:process:GetSystemDEPPolicy stub
fixme:process:SetProcessDEPPolicy (0): stub
Error: API mismatch: the NVIDIA kernel module has version 280.13,
but this NVIDIA driver component has version 275.21. Please make
sure that the kernel module and all NVIDIA driver components
have the same version.
err:winediag:X11DRV_WineGL_InitOpenglInfo Direct rendering is disabled, most likely your OpenGL drivers haven't been installed correctly
Error: API mismatch: the NVIDIA kernel module has version 280.13,
but this NVIDIA driver component has version 275.21. Please make
sure that the kernel module and all NVIDIA driver components
have the same version.
fixme:dbghelp:elf_search_auxv can't find symbol in module

I think that NVIDIA driver component has version 275.21 is an old version. I am not sure how to fix this though, as I don't want to break things so that Octane doesn't work (it does now, and wonderfully so). NVIDIA drivers are hard enough just to keep working under linux.