I remember a discussion on Modo forum, where someone qualify MoI mesher been "bad" because the topology was not sub-d friendly :)

Btw I dont know for C4D, by when you start messing with MoI topology in Modo (merging, flipping poly etc), you just introduce all kind of shading artefact because the vertex normal is not right anymore.
Otherwise, the rendering is just perfect with MoI ngones, I dont remember any glitches since one year or so ...