Hi Mike, I don't think that WINE supports enough Windows functionality to enable MoI to run.

If you have an Intel Mac, it is possible to run it by using Apple's Boot Camp system to install Windows on to the Mac so that you have the option to start either Mac OS or Windows when you turn the machine on. That will definitely work.

Also some people have reported some success with the latest beta version of Parallels, for running MoI more directly inside the Mac OS.

- Michael