MoI runs great under WINE. But sadly there's a bug in the Nvidia driver that makes it a bit problematic for Nvidia users. In short - display state seems to be always at least one action behind of the real state. So for example you wouldn't get correct highlighting on mouse hover and so on.

https://vimeo.com/manage/296282117/general

But it seems a valid workaround has been posted on WINE's bugzilla:
https://bugs.winehq.org/show_bug.cgi?id=25912

It seems that setting this environment variable does the trick:
__GL_MaxFramesAllowed=1

At this point I don't know whether this workaround has any other implications - but so far it seems it makes MoI usable for Nvidia Linux users :).