I've found that I have to be very careful with fillets and chamfers as if I want to edit object itself after 3D printing it (to make adjustments for the part needed) it's really painful if it has filleted edges.

This is biggest downside of moi comparing to DSM that edits of finished models are more time consuming.
Also the fillets and chamfers have different math or whatever that MOI cannot handle them as good as DSM.

Aside those two above MOI is better on all levels I think.

Bad news for me that those two things are ones I use most often.

I know you used chamfers just as an example, but it reminded me of this :/