Regarding shortcuts:

ctrl-X, ctrl-S, ctrl-O, ctrl-N, F1 for example work right out of the box.
I was not able to assign the cmd key instead of the ctrl key. The Key field remains blank when I tried to fill in cmd-X for example.

ctrl-C and ctrl-V do nothing. This is bad since there's no menu alternative.

Trying to assign the Backspace key instead of the Delete key also leaves the Key field blank. But ctrl-X works fine as an alternative.