Someone posted a while ago a modern UI for Moi...and to me it looked nice...
for existing user it does not make a difference...all I want is speed...for new user..I think its a plus.
Now..
Moi with...
Xnurbs
Polymodeling like Rhino
Materials

Someone mentioned the managing of the scripts...I think this is a good idea...sometimes I forget what I have installed and need to go thru the list...and cannot find it lol.
For instance...
Plasticity you can add your most used items to favorites
3dcoat spacebar I think it was you press it and you can set your most used commands
Nvil3d you can set your special commands on the side...
to me Nvil does it better

The way I have Moi3d setup it runs like a dream..I use it for everything lol....but do I need Rhino...not really but I do want it ..yes ...for the plug ins or certain features.
What makes Moi special is the scripts the were created for a specific user case.