If you want to try setting up an exception for the MoI process to not be messed with by Sophos, you may need to set it for both the main MoI app and also the additional moi_commandprocessor executable which is located inside the app bundle (right-click and choose "Show package contents" to go into the app bundle) inside moi.app/Contents/Frameworks/moi_commandprocessor . Those are the 2 processes that need to communicate with each other.

If Sophos is intercepting and analyzing named pipe traffic between those 2 processes it could cause a slowdown like you are describing.

- Michael